Endocrine Abstracts

Background: Previous research show that autoimmune adrenal insufficiency develops gradually over time and inexorably results in a total inability to produce adrenal steroids. However, growing evidence suggest that a few patients preserve some steroid producing capacity.Aim: To explore the frequency of residual cortisol production and possible clinical consequences in patients with autoimmune Addison´s disease (AAD).Material an...

BackgroundResidual adrenocortical function (RAF) is present in one third of patients with autoimmune Addison’s disease (AAD), yet its clinical significance remains unknown.ObjectiveTo investigate if biomarker profiles of cardiovascular disease and inflammation are different in patients with AAD and RAF compared to patients without RAF and healthy controls.Material and methods<p...

Introdution: Pituitary apoplexy (PA) is a rare clinical syndrome caused by sudden hemorrhage or infarction of the pituitary gland. PA may be the form of presentation of a pituitary tumor or occur during follow-up of a previously diagnosed macroadenoma. A high suspicion índex is required to establish a timely diagnosis.Case report: A 54-year-old man was referred to Endocrinology department (04/2015) due to a pituitary macroadenoma. He reported sexual...

Gitelman’s Syndrome (GS) is a rare autosomal recessive salt-losing tubulopathy of young adults, characterized by secondary hyperaldosteronism, hypokalemia, hypomagnesemia, hypocalciuria and metabolic alkalosis. It is caused by mutations in SLC12A3 gene. Hypercalcemia due to hypocalciuria in these patients is extremely rare and requires further evaluation.A 25-year-old normotensive female was referred to Endocrinology clinic for evaluation o...

Introduction: Barakat syndrome is a very rare disease and an uncommon aetiology of hypocalcaemia. Also known as HDR syndrome it is an autosomal dominant disorder characterised by hypoparathyroidism, sensorineural deafness and renal disease.Clinical case: A 59-year-old Caucasian woman was admitted to our Endocrinology ward in May 2014 due to hypocalcaemia despite being medicated with oral calcium. At 35 years old a diagnosis of hypoparathyroidism was esta...

The authors studied the effect of one year of therapy with rhGH on growth velocity in patients with growth hormone deficiency (GHD). We analyzed 120 patients (85 boys and 35 girls), 6–21.5 years of age (mean 14.2±3.0) treated in Department of Endocrinology and Diabetology for Children and Adolescents, Medical University of Wrocław. Patients received rhGH in a dose of 0.7IU/Kg/week. Partial GHD was diagnosed in 71 cases (52 boys and 19 girls), complete GHD was ...

Hyperthyroid patients show an impaired response or even resistance to digoxin treatment.Objectives: 1. Are there any differences in the pharmacokinetics of a single oral dose of digoxin between hyperthyroid and euthyroid patients? 2. Does simultaneous administration of digoxin and methimazole or digoxin and acebutolol affect the pharmacokinetics of a single oral dose of dogoxin? 3. Does methimazole-induced euthyroidism change the pharmacokinetics of a si...

Background: Aggressive prolactinomas are rare neoplasms that are characterized by rapid growth and usually large tumor size, invasion of adjacent structures, an aggressive clinical behavior with little response to conventional treatment, high rate of recurrence, and elevated morbidity and mortality.Case Report: 48-year-old woman diagnosed with life-threatening aggressive prolactinoma was referred to us for evaluation of complementary therapy after therap...

Introduction: Hypoparathyroidism is characterized by hypocalcemia and low or inappropriately normal levels of PTH. The most common cause of hypoparathyroidism is iatrogenic due to anterior neck surgery. In recent years it was documented that vitamin D insufficiency is widespread.Aim: To investigate the cause of hypocalcemia in thyroidectomized patients with PTH within the reference range.Methods: Retrospective review of clinical re...

Introduction: Treatment of hyperthyroidism in older adults is crucial to reduce its morbidity and mortality. Radioactive iodine has been widely used in this age group due to its efficacy, safety and cost-effectiveness.Aim: To determine the efficacy of 131I for treatment of hyperthyroidism in the elderly.Methods: Retrospective study of 86 hyperthyroid patients aged ≥65 years who performed radioiodine therapy. We eva...